Acetone (found in Nail polish remover) | Acetone reported in reaction products in e-cigarette emissions (highest reported amount 1.4mg/mL liquid).
| Australian Government, National Industrial Chemicals Notification and Assessment Scheme (NICNAS),
Non-nicotine liquids for e-cigarette devices in Australia: chemistry and health concerns report, Department of Health, 2019. | Table 7 p.28. Australia |
Acetone (found in nail polish remover) | Acetone was found in ACCC 2016 sample testing of emissions of e-liquids. |
Australian Government, NICNAS, 2019. | p.36 |
Acetone (found in nail polish remover) | Acetone is identified in scientific literature as being of concern to human health due to the carbonyl reaction products in e-cigarette emissions. |
Australian Government, NICNAS, 2019. | p.49 |
Acetone (found in nail polish remover) | Acetone was detected in 13 brands of Japanese e-cigarettes. |
National Academy of Sciences 2018 cites Uchiyama S, Ohta K, Inaba Y, Kunugita N. Determination of carbonyl compounds generated from the e-cigarette using coupled silica cartridges impregnated with hydroquinone and 2,4-dinitrophenylhydrazine, followed by high- performance liquid chromatography. Analytical Sciences. 2013;29(12):1219–1222. | |
Hydroxyacetone (consists of a primary alcohol substituent on acetone) | Hydroxyacetone was identified as a chemical ingredient in e- cigarette liquids. |
Australian Government, NICNAS, 2019 cites Sleiman, M, Logue, JM, Montesinos, VN, Russell, ML, Litter, MI, Gundel, LA & Destaillats, H 2016, 'Emissions from Electronic Cigarettes: Key Parameters Affecting the Release of Harmful Chemicals', Environ Sci Technol, vol. 50, no. 17, pp. 9644-51. | Appendix Table A2 p.66 |
Acetone (found in nail polish remover) | Acetone is identified as a chemical contaminant in e- cigarette liquids. |
Australian Government, NICNAS, 2019 cites Sleiman et al. 2016. | Table 9 p.32, Appendix Table A3 p.74 |
Acetone (found in nail polish remover) | Acetone is a chemical reaction product in e-cigarette emissions during e-cigarette use | Farsalinos, Voudris, and Poulas 2015; Geiss et al. 2015; Jensen, Strongin, and Peyton 2017; Kosmider et al. 2014; Lee et al. 2017; Margham et al. 2016; Ogunwale et al. 2017; Garcia-Gomez et al. 2016; Uchiyama et al. 2016 cited by
Australian Government, NICNAS, 2019. | Appendix Table A5 p.86. |
Acetone (found in nail polish remover) | Acetone found in JUUL e-cigarette emissions. Acetone is one of the chemicals associated with some of the same diseases as nicotine, formaldehyde and particulate matter, but also show direct relationships with 39 unique diseases including diabetes mellitus type 1 and amyotrophic lateral sclerosis. | Grondin CJ, Davis AP, Wiegers JA, Wiegers TC, Sciaky D, Johnson RJ, et al. Predicting molecular mechanisms, pathways, and health outcomes induced by Juul e-cigarette aerosol chemicals using the Comparative Toxicogenomics Database. Current Research in Toxicology. 2021;2:272-81 | p. 276-278. |
Acrolein (found in herbicide) | Acrolein reported in reaction products in e-cigarette emissions (highest reported amount 10mg/ml liquid). |
Australian Government, NICNAS, 2019. | Table 7 p.28 |
Acrolein (found in herbicide) | Acrolein identified as a contaminant chemical in e-liquids. |
Australian Government, NICNAS, 2019. | Table 9 p32 |
Acrolein (found in herbicide) | Acrolein reported in the scientific literature at levels above cut-offs specified in the schedule (and relevant to e-cigarette liquids) (CAS number 107-02-8). |
Australian Government, NICNAS, 2019. | p.35 |
Acrolein (found in herbicide) | The National Academy of Sciences conducted a comprehensive scientific review to inform understanding of the public health impact of nicotine containing e-cigarette devices (National Academies of Sciences 2018). “There is substantial evidence that some chemicals present in e- cigarette aerosols (e.g. formaldehyde, acrolein) are capable of causing DNA damage and mutagenesis. This supports the biological plausibility that long-term exposure to e-cigarette aerosols could increase risk of cancer and adverse reproductive outcomes. Whether or not the levels of exposure are high enough to contribute to human carcinogenesis remains to be determined.” | National Academies of Sciences, E, and Medicine 2018, Public Health Consequences of E- Cigarettes, ed. Kathleen Stratton, Leslie Y. Kwan and David L. Eaton, The National Academies Press, Washington, DC, p. 774. Cited by
Australian Government, NICNAS, 2019. | p.44 |
Acrolein (found in herbicide) | Acrolein is associated with irreversible lung damage, and irritation. | Allen et al. 2016; Clapp and Jaspers 2017 cited by
Australian Government, NICNAS, 2019. | |
Acrolein (found in herbicide) | Research confirms the presence of diacetyl and other flavouring chemicals in flavoured e-cigarettes, of concern due to the association between diacetyl and bronchiolitis obliterans and other severe respiratory diseases among workers inhaling heated vapours containing diacetyl. | Allen, JG, Flanigan, SS, LeBlanc, M, Vallarino, J, MacNaughton, P, Stewart, JH & Christiani, DC 2016, 'Flavoring Chemicals in E-Cigarettes: Diacetyl, 2,3-Pentanedione, and Acetoin in a Sample of 51 Products, Including Fruit-, Candy-, and Cocktail-Flavored E-Cigarettes', Environ Health Perspect, vol. 124, no. 6, pp. 733-9. | |
Acrolein (found in herbicide) | Common flavouring agents, which are often present at high concentrations in e-liquids and e-cig aerosols, are chemically similar to known airway irritants and sensitizers, and have been reported to cause occupational asthma. Moreover, e-cig exposures of some of these chemicals may exceed workplace exposure standards. & There is no data on the potential long-term effects of e-cig use and incidence or exacerbation of asthma. | Clapp, PW & Jaspers, I 2017, 'Electronic Cigarettes: Their Constituents and Potential Links to Asthma', Curr Allergy Asthma Rep, vol. 17, no. 11, p. 79. | |
Acrolein (found in herbicide) | Acrolein is a carbonyl reaction product found in e-cigarette emissions identified in the scientific literature as being of concern to human health. |
Australian Government, NICNAS, 2019. | p.49 |
Acrolein (found in herbicide) | Acrolein a chemical contaminant in e-liquids. | Fagan et al. 2017; Sleiman et al. 2016 cited by
Australian Government, NICNAS, 2019 | p.74 |
Acrolein (found in found in herbicide) | Acrolein listed as a chemical ingredient in e-cigarette emissions. | Beauval et al. 2017; Farsalinos et al. 2018; Farsalinos and Voudris 2018; Farsalinos, Voudris, and Poulas 2015; Flora et al. 2017; Geiss et al. 2015; Hutzler et al. 2014; Jensen, Strongin, and Peyton 2017; Khlystov and Samburova 2016; Laugesen 2015; Margham et al. 2016; Ogunwale et al. 2017; Sala et al. 2017; Sleiman et al. 2016; Uchiyama et al. 2013; Uchiyama et al. 2016; Wang et al. 2017 cited by
Australian Government, NICNAS, 2019. | Appendix Table A5 p. 86 |
Acrolein (found in found in herbicide) | There is concern regarding the production of toxic aldehydes including acrolein, formaldehyde, and acetal dehyde during the heating of the e-liquid, but the clinical importance of this is not yet known. | Daniel Overbeek, Alexandra Kass, Laura Chiel, Edward Boyer, Alicia Casey ‘A review of toxic effect of electronic cigarettesvaping in adolescents and young adults’ Critical Reviews in Toxicology 50:6 531-538. | p.533 |
2-chlorophenol (found in disinfectant /cleaning products/ insecticide) | Identified 2-chlorophenol as a contaminant in testing of 10 e- liquids (maximum concentration 0.47%). |
Australian Government, NICNAS, 2019. | Table 12 p. 38 |
2-chlorophenol (found in disinfectant/cleaning products/ insecticide) | 2-chlorophenol was identified in all 10 e-liquids tested. | Chivers E, Janka M, Franklin P, Mullins B, Larcombe A. Nicotine and other potentially harmful compounds in “nicotine‐free” e‐cigarette liquids in Australia. Medical journal of Australia. 2019;210(3):127-8. | Table p. 127 |
2-chlorophenol (found in disinfectant/ cleaning products/ insecticide) | Found 2‐chlorophenol in 27 fresh and 30 aged samples, at concentrations of up to 206 mg/L. Similar chemicals have been identified as pesticide or herbicide residues or decomposition by-products in canola oil, from which glycerol is derived. While not as ubiquitous as in our earlier study, this acutely toxic chemical, used in disinfectants and insecticides, remains a problem for the e-liquid manufacturing process. | Alexander Larcombe, Sebastien Allard,*, Paul Pringle, Ryan Mead-Hunter, Natalie Anderson, Benjamin Mullins/ Chemical analysis of fresh and aged Australian e-cigarette liquids. Med J Aust 2022; 216 (1): 27-32 | Box 2 and p. 31 |
2-chlorophenol (found in disinfectant/ cleaning products/ insecticide) | Of the other chemicals detected, 2-chlorophenol, classified as acutely toxic by the Globally Harmonized System of Classification and Labelling of Chemicals, was identified in all e-liquids. Probably an excipient contaminant, 2-chlorophenol is commonly used in insecticides, herbicides, and disinfectants. There is no Safework Australia exposure standard for 2-chlorophenol, but it is known to be a respiratory and dermal irritant. | Chivers E, Janka M, Franklin P, Mullins B, Larcombe A. Nicotine and other potentially harmful compounds in “nicotine‐free” e‐cigarette liquids in Australia. Medical journal of Australia. 2019;210(3):127-8. | p.127, 128 |
Pulegone (found in insecticide) | Pulegone was identified as a Chemical from the scientific literature as present in e-cigarette liquids and also listed in the Poisons Standard. Pulegone identified as a chemical ingredient in e-cigarette liquids. |
Australian Government, NICNAS, 2019. | Table 9 p.32, Appendix Table A2 p.71 |
Pulegone (found in insecticide) | Mint flavour was one of the most abundant volatile compounds identified in the selected refill liquids – pulegone was one of main compounds in mint flavoured e-cigarettes. | Geiss O, Bianchi I, Barahone F, Barrero-Moreno J, ‘Characterisation of mainstream and passive vapours emitted by selected electronic cigarettes’ International Journal of Hygiene and Environment Health Vol 218, issue 1, January 2015:169-180. | p.172 Table 2 |
Pulegone (found in insecticide) | One “menthol” e-liquid contained no menthol and may have instead contained potentially carcinogenic analogues such as pulegone, or synthetic ‘coolants’ such as N-ethyl-p- menthane-3-carboxamide. | Larcombe A, Allard S, Pringle P, Mead-Hunter R, Anderson N, Benjamin Mullins/ Chemical analysis of fresh and aged Australian e-cigarette liquids. Med J Aust 2022; 216 (1): 27-32 | p.30 |
Pulegone (found in insecticide) | This research found e-cigarettes expose users to pulegone, which is a concern because of its known carcinogenicity. | Omaiye EE, Luo W, McWhirter KJ, Pankow JF, Talbot P. Flavour chemicals, synthetic coolants and pulegone in popular mint-flavoured and menthol-flavoured e-cigarettes. Tobacco control. 2021:tobaccocontrol-2021-056582. | |
Chemicals/flavourings in vapes - rare earth elements (REE) | Use of e-cigarettes is a potential source of - rare earth elements REE. However, these elements were detected at low concentrations. | Badea M, Luzardo OP, González-Antuña A, Zumbado M, Rogozea L, Floroian L, Alexandrescu D, Moga M, Gaman L, Radoi M, Boada LD, Henríquez-Hernández LA. Body burden of toxic metals and rare earth elements in non-smokers, cigarette smokers and electronic cigarette users. Environ Res. 2018 Oct;166:269-275. doi:10.1016/j.envres.2018.06.007. Epub 2018 Jun 13. PMID: 29908458. | |
Formaldehyde, heavy metals, particulate matter and flavouring chemicals | “E-cigarettes may expose users to chemicals and toxins such as formaldehyde, heavy metals, particulate matter and flavouring chemicals, at levels that have the potential to cause adverse health effects.” |
NHMRC. CEO Statement: Electronic cigarettes: National Health and Medical Research Council; 2017 | Australia |
Various chemical substances and ultrafine particles | Various chemical substances and ultrafine particles known to be toxic, carcinogenic and/or to cause respiratory and heart distress have been identified in e-cigarette aerosols, cartridges, refill liquids and environmental emissions. Wide ranges in the levels of chemical substances such as tobacco-specific nitrosamines, aldehydes, metals, volatile organic compounds, phenolic compounds, polycyclic aromatic hydrocarbons, flavours, solvent carriers, tobacco alkaloids and drugs have been reported in e-cigarette refill solutions, cartridges, aerosols and environmental emissions. | Cheng T. Chemical evaluation of electronic cigarettes. Tobacco Control. 2014; 23:ii11–ii17. Bein K, Leikauf GD. Acrolein–a pulmonary hazard. Molecular Nutrition & Food Research. 2011;55(9):1342-1360. | |
E-cigarette aerosol is not harmless ‘water vapour’. | The e-cigarette aerosol that users breathe from the device and exhale can contain harmful and potentially harmful substances, including:
- nicotine
- ultrafine particles that can be inhaled deep into the lungs
- flavourings such as diacetyl, a chemical linked to a serious lung disease
- volatile organic compounds
- cancer-causing chemicals
- heavy metals such as nickel, tin, and lead.
The aerosol that users inhale and exhale from e-cigarettes can expose both themselves and bystanders to harmful substances. | Centre for Disease Control and Prevention
CDCDaniel Overbeek, Alexandra Kass, Laura Chiel, Edward Boyer, Alicia Casey ‘A review of toxic effect of electronic cigarettes vaping in adolescents and young adults’ Critical Reviews in Toxicology, 50:6 531-538. | USA
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