Local paramedics will soon be handed the keys to Tamworth's new ambulance station with construction now complete on the state-of-the-art facility.

Minister for Health Ryan Park said the new station on Piper Street is replacing the station on Marius Street, which has been faithfully serving the community for almost 100 years.

Mr Park said the Marius Street ambulance station, which opened in 1926, will remain operational until the new Piper Street station assumes operational duties.

"We have now reached the final milestone in the delivery of Tamworth's new ambulance station, with construction now complete," Mr Park said.

"This is a big step towards providing local paramedics with a high-quality base and the latest facilities and equipment to meet the current and future emergency care needs of the local community.

"In the coming months, we can expect to see NSW Ambulance operations transition over to the new station.

"This is part of our commitment to invest in rural and regional health infrastructure to support better health outcomes for local communities," Mr Park said.

NSW Ambulance will shortly commence operational commissioning activities, which includes testing systems and adding the finishing touches to the internal fit-out, ahead of the station becoming operational in the coming months.

The new station includes internal parking for up to 12 emergency ambulance vehicles, staff rest facilities, administration and office areas, logistics and storage areas, an internal wash bay and staff parking.

The $232 million RAIR program is delivering 54 new or upgraded ambulance stations. It is the single largest investment in regional NSW Ambulance's 127-year history.